Compound ID | 2277

Update compound information

Arylfluorosulfate derivative compound 81 (Ar-O-SO2-F)

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Staphylococcus aureus, Enterococcus faecium, Staphylococcus epidermidis, Bacillus subtilis
Propensity to select resistant mutants: No
Description: Synthetic compound made by Sulfur fluoride exchange (SuFEx) click chemistry; has weak cytotoxic effect against HEK293T cells (41 uM, vs 3.13-12.5 uM MIC in bacteria); showed two-fold increase in survival rate in comparison to vancomycin
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 392.35
Iso. SMILES: FS(OC1=CC(O)=CC(/C=C/C2=CC=C(OS(F)(=O)=O)C=C2)=C1)(=O)=O
InChI Key: DEMJKWWFHXOPEN-OWOJBTEDSA-N
Can. SMILES: C(=C\C1=CC(=CC(=C1)O)OS(=O)(=O)F)/C2=CC=C(C=C2)OS(=O)(=O)F
InChI: InChI=1S/C14H10F2O7S2/c15-24(18,19)22-13-5-3-10(4-6-13)1-2-11-7-12(17)9-14(8-11)23-25(16,20)21/h1-9,17H/b2-1+
External links:
Citation: https://www.pnas.org/doi/10.1073/pnas.2103513118

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.