Compound ID | 2279
Horine
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive |
| Details of activity: | Active against vancomycin resistant Enterococci, methicillin-resistant Staphylococcus aureus, and Staphylococcus aureus; targets bacterial membrane |
| Propensity to select resistant mutants: | No |
| Description: | Synthetic compound (horizontal helix); not cytotoxic to human cells (human liver & kidney cells LD50 at >80 uM and human lung fibroblasts LD50 >25 uM) at MIC required to inhibit VRE and MRSA (MIC 2-4 uM); no murine nephrotoxicity observed; systemic efficacy observed vs S. aureus infection (87.5% mouse survival rate) |
| Year first mentioned: | 2020 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.pnas.org/doi/10.1073/pnas.2005540117 |
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