Compound ID | 228

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KS100

Class: Antivirulence agent

Agent Type: Small molecule; Indirect acting; Antivirulence;
Spectrum of activity: Gram-negative
Mechanism of action: T6SS inhibitor
Target Pathogen: Active against Vibrio cholerae
Propensity to select resistant mutants: Yes
Institute where first reported: Department of Clinical Microbiology, Clinical Bacteriology and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden
Year first mentioned: 2014
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: N#CC1=C(C#N)C=CC(OC=2C=CC3=C(C2)C4=CC(=CC=C4S3(=O)=O)OC5=CC(C#N)=C(C#N)C=C5)=C1
InChI Key: NSCAGQDRMAVRJV-UHFFFAOYSA-N
Can. SMILES: C1=C(C#N)C(=CC(=C1)OC2=CC=C3C(=C2)C4=C(C=CC(=C4)OC5=CC=C(C#N)C(=C5)C#N)S3(=O)=O)C#N
InChI: InChI=1S/C28H12N4O4S/c29-13-17-1-3-21(9-19(17)15-31)35-23-5-7-27-25(11-23)26-12-24(6-8-28(26)37(27,33)34)36-22-4-2-18(14-30)20(10-22)16-32/h1-12H
External links:
Citation: http://aac.asm.org/content/58/7/4123.full

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