Compound ID | 2280
Verine
Class: Antimicrobial peptide
| Agent Type: | Synthetic; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Unknown |
| Target Pathogen: | Active against vancomycin resistant Enterococci, methicillin-resistant Staphylococcus aureus, and Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii |
| Propensity to select resistant mutants: | No |
| Description: | Synthetic compound (vertical spiral structure); not cytotoxic to human cells (human liver & kidney cells LD50 at >80 uM and human lung fibroblasts LD50 >25 uM) at MIC required to inhibit VRE and MRSA (MIC 2-4 uM); no murine nephrotoxicity observed; systemic efficacy observed vs K. pneumoniae infection (81.8% mouse survival rate) |
| Year first mentioned: | 2020 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.pnas.org/doi/10.1073/pnas.2005540117 |
AntibioticDB is supported by GARDP.
If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions
The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.