Compound ID | 2281
Peptide K6
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Pseudomonas aeruginosa and Staphylococcus aureus; disrupts integrity of bacterial cell membrane |
| Propensity to select resistant mutants: | No |
| Description: | Synthetic compound; shows <10% haemolysis and <20% RAW264.7 macrophages cytotoxicity at 4 to 64 uM (MIC at 4 uM); clears P. aeruginosa and S. aureus mouse infection model |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.pnas.org/doi/10.1073/pnas.2219679120 |
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