Compound ID | 2282
Shapeshifting vancomycin dimer (SVD 6d)
Class: Glycopeptide
| Spectrum of activity: | Gram-positive |
| Details of activity: | Active agaisnt vancomycin-susceptible , -intermediate, -resistant Enterococcus, and vancomycin-resistant Staphylococcus aureus; has a dynamic binding interaction destabilising complex formed between MurJ and lipid II |
| Description: | Synthetic compound made by 'click chemistry' - vancomycin derivative; dimers have a shapeshifting modality; in vitro toxicity test showed no decrease in HEK293 and HepG2 cell line viability when used at same concentration as vancomycin; treated Galleria mellonella VRE infection with 70% larval survival vs 40% larval survival for vancomycin |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.pnas.org/doi/10.1073/pnas.2208737120 |
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