Compound ID | 2283

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Mitoxantrone

Synonym(s): MTX

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Induces reactive oxygen species and DNA damage
Target Pathogen: Active against vancomycin-resistant Enterococcus, methicillin-resistant Staphylococcus aureus, vancomycin-susceptible Enterococcus, vancomycin-susceptible Staphylococcus aureus, Enterococcus faecium and E. faecium
Description: Synthetic compound; repurposed antineoplastic agent; inhibits S. aureus infection in mouse wound; synergistic in vitro and in vivo effect with vancomycin and stimulates macrophages in clearing bacteria
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 444.48
Iso. SMILES: C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
InChI Key: KKZJGLLVHKMTCM-UHFFFAOYSA-N
Can. SMILES: C1=C(C2=C(C(=C1)NCCNCCO)C(=O)C3=C(C(=CC=C3O)O)C2=O)NCCNCCO
InChI: InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/4212
Citation: https://www.science.org/doi/10.1126/sciadv.add9280

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