Compound ID | 2284
Omega 76
Synonym(s): Omega-76 | Ω76
Class: Antimicrobial peptide
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent. Disrupts integrity of cell membrane |
| Target Pathogen: | Active against carbapenem- and tigecycline-resistant Acinetobacter baumannii |
| Description: | Synthetic compound; no cytotoxicity observed against HeLa cells (>128 mg/l, highest concentration tested) and negligible activity against HaCat cell line ; no nephrotoxic or hepatotoxic effects in mice; treats carbapenem- and tigecycline-resistant A. baumannii in mouse peritoneal model of infection |
| Year first mentioned: | 2019 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.science.org/doi/10.1126/sciadv.aax1946 |
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