AZ1

Synonym(s): sulfonyl piperazine

Class: Lipopolysaccharide synthesis inhibitor

Spectrum of activity:	Gram-negative
Details of activity:	Active against Klebsiella pneumoniae LpxH
Description:	Synthetic compound
Year first mentioned:	2015
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC(=O)N1CCC2=CC(=CC=C21)S(=O)(=O)N3CCN(CC3)C4=CC(=CC=C4)C(F)(F)F
Isomeric SMILES:	CC(=O)N1CCC2=CC(=CC=C21)S(=O)(=O)N3CCN(CC3)C4=CC(=CC=C4)C(F)(F)F
InChI:	InChI=1S/C21H22F3N3O3S/c1-15(28)27-8-7-16-13-19(5-6-20(16)27)31(29,30)26-11-9-25(10-12-26)18-4-2-3-17(14-18)21(22,23)24/h2-6,13-14H,7-12H2,1H3
InChI Key:	JRTCXCIMCOKGMN-UHFFFAOYSA-N

External links:
Guide to Pharmacology:	AZ1
Main Source:	https://www.pnas.org/doi/10.1073/pnas.1912876117
Citations:	https://journals.asm.org/doi/10.1128/jb.02552-14 https://pubs.acs.org/doi/10.1021/acsinfecdis.8b00364