Compound ID | 2298

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AZ1

Synonym(s): sulfonyl piperazine

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Klebsiella pneumoniae LpxH
Description: Synthetic compound
Year first mentioned: 2015
Development status: Experimental
Chemical structure(s):
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Molecular weight: 453.48
Iso. SMILES: CC(=O)N1CCC2=CC(=CC=C21)S(=O)(=O)N3CCN(CC3)C4=CC(=CC=C4)C(F)(F)F
InChI Key: JRTCXCIMCOKGMN-UHFFFAOYSA-N
Can. SMILES: CC(=O)N1CCC2=CC(=CC=C21)S(=O)(=O)N3CCN(CC3)C4=CC(=CC=C4)C(F)(F)F
InChI: InChI=1S/C21H22F3N3O3S/c1-15(28)27-8-7-16-13-19(5-6-20(16)27)31(29,30)26-11-9-25(10-12-26)18-4-2-3-17(14-18)21(22,23)24/h2-6,13-14H,7-12H2,1H3
External links:
Guide to Pharmacology: AZ1
Citations:
  • https://journals.asm.org/doi/10.1128/jb.02552-14
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.8b00364
  • https://www.pnas.org/doi/10.1073/pnas.1912876117

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