Compound ID | 230

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KKL-35

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Trans-translation inhibitor
Target Pathogen: Active against Legionella pneumophila
Propensity to select resistant mutants: Yes
Description: Synthetic compound; contains oxadiazole scaffold
Institute where first reported: Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, USA
Year first mentioned: 2013
Development status: Experimental
Chemical structure(s):
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Molecular weight: 317.7
Iso. SMILES: C1=CC(=CC=C1C2=NN=C(O2)NC(=O)C3=CC=C(C=C3)Cl)F
InChI Key: ZIICPNCCHIUJSX-UHFFFAOYSA-N
Can. SMILES: C1=C(C=CC(=C1)Cl)C(=O)NC2=NN=C(C3=CC=C(C=C3)F)O2
InChI: InChI=1S/C15H9ClFN3O2/c16-11-5-1-9(2-6-11)13(21)18-15-20-19-14(22-15)10-3-7-12(17)8-4-10/h1-8H,(H,18,20,21)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/4128171
Citations:
  • https://journals.asm.org/doi/10.1128/aac.01459-17
  • https://www.pnas.org/doi/full/10.1073/pnas.1302816110

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