Compound ID | 2300

Update compound information

JH-LPH-33

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Klebsiella pneumoniae LpxH and Escherichia coli LpxH
Description: Synthetic compound derivative of AZ1 (sulfonyl piperazine)
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 487.92
Iso. SMILES: CC(=O)N1CCC2=C1C=CC(=C2)S(=O)(=O)N3CCN(CC3)C4=CC(=CC(=C4)C(F)(F)F)Cl
InChI Key: PDEIRNVIXFZSSJ-UHFFFAOYSA-N
Can. SMILES: CC(=O)N1CCC2=CC(=CC=C21)S(=O)(=O)N3CCN(CC3)C4=CC(=CC(=C4)C(F)(F)F)Cl
InChI: InChI=1S/C21H21ClF3N3O3S/c1-14(29)28-5-4-15-10-19(2-3-20(15)28)32(30,31)27-8-6-26(7-9-27)18-12-16(21(23,24)25)11-17(22)13-18/h2-3,10-13H,4-9H2,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/145946109
Citation: https://www.pnas.org/doi/10.1073/pnas.1912876117
Patent: WO2021072369A1

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