Compound ID | 2301
NL1
Class: Small molecule antibacterial agent
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Staphylococcus aureus and Pseudomonas aeruginosa; inhibits bacterial cystathionine γ-lyase that generates H2S (protects bacteria from oxidative stress); suppresses H2S-mediated cellular defence against gentamicin |
| Description: | Synthetic compound discovered from structure-based virtual screening; small molecule with acetyl glycine central indole moiety; potentiates antibiotics by targeting general defence (H2S biogenesis system) mechanism of bacteria |
| Year first mentioned: | 2021 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.science.org/doi/10.1126/science.abd8377 |
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