Compound ID | 2304
Oligoamidine 3
Synonym(s): Oligomer 3
Class: Membrane-active agent
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Bacillus subtilis, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, and Mycobacterium smegmatis; selectively disrupts integrity of bacterial cytoplasmic membrane and binds to bacterial DNA |
| Description: | Synthetic compound (antimicrobial polymer oligoamidine); when tested at MIC, 90% viability was observed on human embryonic kidney (HEK) 293 and NIH/3T3 |
| Year first mentioned: | 2021 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.science.org/doi/10.1126/sciadv.abc9917 |
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