SAAP-148

Synonym(s): P148

Class: Antimicrobial peptide (synthetic antimicrobial and antibiofilm peptide [SAAP], LL-37 derivative)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Active against ESKAPE pathogens; disrupts integrity of cytoplasmic membrane
Propensity to select resistant mutants:	No
Description:	Synthetic compound; safe and showed no adverse effect when applied up to 1% as ointment to skin wound; poor antimicrobial efficacy seen in rat wound infection model
Year first mentioned:	2018
Development status:	Experimental

Chemical structure(s):

External links:
Structure link:	https://pubchem.ncbi.nlm.nih.gov/substance/447412853
Guide to Pharmacology:	SAAP-148
Main Source:	https://www.science.org/doi/10.1126/scitranslmed.aan4044
Citation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891976/