Compound ID | 2306

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LPC-233

Class: Lipopolysaccharide synthesis inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Pseudomonas aeruginosa LpxC
Description: No detectable adverse cardiovascular toxicity in dogs at 100 milligrams per kilogram; in preclinical evaluation
Year first mentioned: 2023
Development status: Preclinical evaluation
Chemical structure(s):
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Molecular weight: 376.35
Iso. SMILES: C[C@]([C@@H](C(=O)NO)NC(=O)C1=CC=C(C#CC#CC2CC2)C=C1)(C(F)F)O
InChI Key: NPTNDHDCCLLFJE-BEFAXECRSA-N
Can. SMILES: C[C@]([C@@H](C(=O)NO)NC(=O)C1=CC=C(C#CC#CC2CC2)C=C1)(C(F)F)O
InChI: InChI=1S/C19H18F2N2O4/c1-19(26,18(20)21)15(17(25)23-27)22-16(24)14-10-8-13(9-11-14)5-3-2-4-12-6-7-12/h8-12,15,18,26-27H,6-7H2,1H3,(H,22,24)(H,23,25)/t15-,19+/m1/s1
External links:
Guide to Pharmacology: LPC-233
Citation: https://www.science.org/doi/10.1126/scitranslmed.adf5668

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