Compound ID | 2308

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Equisetin

Class: Natural product antibiotic

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, Enterococcus faecalis, Enterococcus casseliflavus, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus
Description: Natural product from marine sponge-derived fungus Fusarium equiseti 33-10; cytotoxicity vs African green monkey kidney cells (Vero cells), lung carcinoma cells (A549), and laryngeal carcinoma cells (Hep2) were 16.74, 19.40, and 15.96 μg/mL (S. aureus MIC 1 ug/mL); shows synergistic effect with colistin
Year first mentioned: 2013
Development status: Experimental
Chemical structure(s):
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Molecular weight: 373.49
Iso. SMILES: C/C=C/[C@@H]1C=C[C@@H]2C[C@@H](CC[C@H]2[C@]1(C)/C(=C\3/C(=O)[C@@H](N(C3=O)C)CO)/O)C
InChI Key: QNQBPPQLRODXET-AIMHRHHOSA-N
Can. SMILES: C/C=C/[C@@H]1C=C[C@@H]2C[C@H](C)CC[C@H]2[C@]1(C)/C(=C\3/C(=O)[C@H](CO)N(C)C3=O)/O
InChI: InChI=1S/C22H31NO4/c1-5-6-15-9-8-14-11-13(2)7-10-16(14)22(15,3)20(26)18-19(25)17(12-24)23(4)21(18)27/h5-6,8-9,13-17,24,26H,7,10-12H2,1-4H3/b6-5+,20-18+/t13-,14-,15-,16-,17+,22-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54684703
Citations:
  • https://pubs.acs.org/doi/10.1021/cb400159f
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00913

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