Compound ID | 231

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Pyridodiazepine amine compound A

Synonym(s): 5-(furan-2-yl)-N-methyl-3-(thiophen-2-yl)-3H-pyrido[2,3-e][1,4]diazepin-2-amine

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. MurI inhibitor
Target Pathogen: Active against Helicobacter pylori
Description: Pyridodiazepine amine
Institute where first reported: AstraZeneca - UK
Year first mentioned: 2014
Development status: Experimental
Chemical structure(s):
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Molecular weight: 322.39
Iso. SMILES: CN=C1C(N=C(C2=C(N1)N=CC=C2)C3=CC=CO3)C4=CC=CS4
InChI Key: DPMRHTYMAOIWBU-UHFFFAOYSA-N
Can. SMILES: CN=C1C(C2=CC=CS2)N=C(C3=CC=CN=C3N1)C4=CC=CO4
InChI: InChI=1S/C17H14N4OS/c1-18-17-15(13-7-4-10-23-13)20-14(12-6-3-9-22-12)11-5-2-8-19-16(11)21-17/h2-10,15H,1H3,(H,18,19,21)
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/135423770
Citations:
  • http://aac.asm.org/content/58/10/6165.full
  • http://aac.asm.org/content/59/4/2337.full
  • https://journals.asm.org/doi/full/10.1128/aac.04410-14

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