Compound ID | 2310

Update compound information

Tetronasin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus aureus and Borellia burgdorferi
Description: Natural product from Streptomyces sp. K1063; cytotoxicity to Vero cells observed at >19.1 uM vs 1.2-1.4 uM MICs; an ionophore
Year first mentioned: 1988
Development status: Experimental
Chemical structure(s):
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Molecular weight: 602.8
Iso. SMILES: C[C@@H]1CCC[C@@H]([C@H]1[C@H](C)C(=C2C(=O)COC2=O)O)/C=C(\CO)/[C@H]3[C@@H](CC[C@H](O3)/C=C/[C@H](C)[C@H]4[C@H](C[C@@H](O4)[C@H](C)OC)C)C
InChI Key: XZJAKURZQBNKKX-ROSSAGPCSA-N
Can. SMILES: C[C@@H]1CCC[C@H](/C=C(\CO)/[C@H]2[C@H](C)CC[C@@H](/C=C/[C@H](C)[C@H]3[C@@H](C)C[C@H]([C@H](C)OC)O3)O2)[C@H]1[C@H](C)C(=C4C(=O)COC4=O)O
InChI: InChI=1S/C35H54O8/c1-19-9-8-10-25(30(19)23(5)32(38)31-28(37)18-41-35(31)39)16-26(17-36)34-21(3)12-14-27(42-34)13-11-20(2)33-22(4)15-29(43-33)24(6)40-7/h11,13,16,19-25,27,29-30,33-34,36,38H,8-10,12,14-15,17-18H2,1-7H3/b13-11+,26-16+,32-31?/t19-,20+,21-,22+,23+,24+,25-,27-,29-,30-,33+,34-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54688698
Citations:
  • https://journals.asm.org/doi/10.1128/aem.54.12.2981-2985.1988
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.3c00171

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