Compound ID | 2314

Update compound information

Plantazolicin

Class: Antimicrobial peptide

Agent Type: Natural product; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent. Dissipates Bacillus membrane potential and localises with cardiolipin
Target Pathogen: Active against Bacillus anthracis
Description: Natural product from Bacillus methylotrophicus FZB42 and Bacillus pumilus
Year first mentioned: 2011
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1336.46
Iso. SMILES: CC[C@H](C)[C@@H](C1=NC(=CO1)C2=NC(=CO2)C3=NC(=CO3)C4=NC(=CO4)C5=NC(C(O5)C)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)C7=C(OC(=N7)C8=C(OC(=N8)C9=CSC(=N9)C%10=C(OC(=N%10)C%11=CSC(=N%11)C(CCCN=C(N)N)N(C)C)C)C)C
InChI Key: SKALCVOFYPVXLA-DUJKJIRYSA-N
Can. SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C1=NC(=CO1)C2=NC(=CO2)C3=NC(=CO3)C4=NC(=CO4)C5=NC(C(C)O5)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)O)NC(=O)C7=C(C)OC(=N7)C8=C(C)OC(=N8)C9=CSC(=N9)C%10=C(C)OC(=N%10)C%11=CSC(=N%11)C(CCCN=C(N)N)N(C)C
InChI: InChI=1S/C63H69N17O13S2/c1-11-28(3)43(74-51(83)46-31(6)93-59(77-46)47-32(7)91-56(78-47)41-27-95-61(73-41)48-33(8)92-57(79-48)40-26-94-60(72-40)42(80(9)10)19-16-20-66-63(64)65)49(81)75-44(29(4)12-2)58-71-38(24-89-58)54-69-36(22-87-54)52-68-37(23-86-52)53-70-39(25-88-53)55-76-45(30(5)90-55)50(82)67-35(62(84)85)21-34-17-14-13-15-18-34/h13-15,17-18,22-30,35,42-45H,11-12,16,19-21H2,1-10H3,(H,67,82)(H,74,83)(H,75,81)(H,84,85)(H4,64,65,66)/t28-,29-,30?,35-,42?,43-,44-,45?/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/101802948
Citations:
  • https://journals.asm.org/doi/10.1128/jb.00784-10
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.5b00115

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