Compound ID | 2318

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TBL-140

Synonym(s): TBL 140  |  TBL140

Class: Small molecule antibacterial agent

Details of activity: Active against Mycobacterium tuberculosis; affects proton motive force
Description: Synthetic compound; effective at killing intracellular Mtb in vitro infection model
Year first mentioned: 2016
Development status: Experimental
Chemical structure(s):
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Molecular weight: 460.53
Iso. SMILES: FC(F)(F)OC=1C=CC(=CC1)OC=2C=CC(=CC2)CNCCNC3[C@@H]4C[C@@H]5C[C@H]3C[C@H](C4)C5
InChI Key: PDNRJVWCZLJZHK-OCHPRTOHSA-N
Can. SMILES: C1=C(C=CC(=C1)OC2=CC=C(C=C2)OC(F)(F)F)CNCCNC3[C@H]4C[C@@H]5C[C@H](C4)C[C@H]3C5
InChI: InChI=1S/C26H31F3N2O2/c27-26(28,29)33-24-7-5-23(6-8-24)32-22-3-1-17(2-4-22)16-30-9-10-31-25-20-12-18-11-19(14-20)15-21(25)13-18/h1-8,18-21,25,30-31H,9-16H2/t18-,19+,20-,21+,25?
External links:
Citation: https://pubs.acs.org/doi/10.1021/acsinfecdis.6b00052

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