ETX1317

Synonym(s): ETX-1317  |  ETX 1317

Class: Beta-lactamase inhibitor (diazabicyclooctane)

Spectrum of activity:	Gram-negative
Details of activity:	Active against Escherichia coli; restores activity of beta-lactams in Enterobacterales
Description:	Synthetic compound; active moiety of the prodrug ETX0282; tested in combination with cefpodoxime, does not inhibit VIM-1 or NDM-1; also inhibits PBP2 of Enterobacterales
Year first mentioned:	2020
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC1=C[C@H](C(=O)N)N2C[C@@H]1N(C2=O)O[C@@H](C(=O)O)F
Isomeric SMILES:	CC1=C[C@@H](N2C[C@@H]1N(C2=O)O[C@@H](C(=O)O)F)C(=O)N
InChI:	InChI=1S/C10H12FN3O5/c1-4-2-5(8(12)15)13-3-6(4)14(10(13)18)19-7(11)9(16)17/h2,5-7H,3H2,1H3,(H2,12,15)(H,16,17)/t5-,6+,7+/m1/s1
InChI Key:	CZCMDCKIUIXEQC-VQVTYTSYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/146170993

External links:
Guide to Pharmacology:	ETX1317
Main Source:	https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00020
Citation:	https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00579