Compound ID | 2319

Update compound information

ETX1317

Synonym(s): ETX-1317  |  ETX 1317

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli; restores activity of beta-lactams in Enterobacterales
Description: Synthetic compound (diazabicyclooctane); active moiety of the prodrug ETX0282; tested in combination with cefpodoxime, does not inhibit VIM-1 or NDM-1; also inhibits PBP2 of Enterobacterales
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 273.22
Iso. SMILES: CC1=C[C@@H](N2C[C@@H]1N(C2=O)O[C@@H](C(=O)O)F)C(=O)N
InChI Key: CZCMDCKIUIXEQC-VQVTYTSYSA-N
Can. SMILES: CC1=C[C@H](C(=O)N)N2C[C@@H]1N(C2=O)O[C@@H](C(=O)O)F
InChI: InChI=1S/C10H12FN3O5/c1-4-2-5(8(12)15)13-3-6(4)14(10(13)18)19-7(11)9(16)17/h2,5-7H,3H2,1H3,(H2,12,15)(H,16,17)/t5-,6+,7+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/146170993
Guide to Pharmacology: ETX1317
Citations:
  • https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00579
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00020

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