Compound ID | 2320

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1,2,3-Triazolylmethaneboronate compound 6q

Class: Beta-lactamase inhibitor

Agent Type: Synthetic; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Class C beta-lactamase inhibitor
Target Pathogen: Active against Acinetobacter baumannii cephalosporinase ADC-7
Description: Synthetic compound (boronic acid transition state inhibitors); restores ceftazidime and cefepime activity in strains with class C and A beta-lactamases
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 310.14
Iso. SMILES: OB(O)CN1N=NC(CNS(=O)(C2=CC=C(C)C=C2)=O)=C1
InChI Key: MACFRAREBBFIBI-UHFFFAOYSA-N
Can. SMILES: CC1=CC=C(C=C1)S(=O)(=O)NCC2=CN(CB(O)O)N=N2
InChI: InChI=1S/C11H15BN4O4S/c1-9-2-4-11(5-3-9)21(19,20)13-6-10-7-16(15-14-10)8-12(17)18/h2-5,7,13,17-18H,6,8H2,1H3
External links:
Citations:
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.7b00153
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00254

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