Compound ID | 2323
Pt@ZIF8
Class: Membrane-active agent
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent. Disrupts integrity of cytoplasmic membrane |
| Target Pathogen: | Active against Aeromonas veronii C4 |
| Description: | Synthetic compound; 1-Hydroxyl-1H-pyridine-2-thione loaded onto a ZIF-8 nanodrug delivery system; inhibited abdominal infection in mice |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acsinfecdis.2c00496 |
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