Compound ID | 2325
Clovibactin
Class: Natural product antibiotic
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against methicillin-resistant Staphylococcus aureus, daptomycin-resistant Staphylococcus aureus, vancomycin-intermediate Staphylococcus aureus, vancomycin-resistant Enterococcus, and Haemophilus influenzae SJ7; binds to pyrophosphate moiety of C55PP, lipid II, and lipid IIIWTA |
| Description: | Natural product from 'uncultured' soil bacteria Eleftheria terrae ssp. Carolina; no cytotoxic activity towards NIH/3T3 and HepG2 mammalian cells at 100 ug/ml (highest tested vs MIC at 0.125 to 2 ug/ml) |
| Year first mentioned: | 2023 |
| Development status: | Experimental |
| External links: | |
| Guide to Pharmacology: | clovibactin |
| Main Source: | https://www.cell.com/cell/fulltext/S0092-8674(23)00853-X |
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