Irresistin-16

Class: Dihydrofolate reductase inhibitor/ membrane-active agent

Spectrum of activity:	Gram-negative
Details of activity:	Active against Neisseria gonorrhoeae; dual mode of action, causing inhibition of dihydrofolate reductase and disrupting integrity of the cytoplasmic membrane
Propensity to select resistant mutants:	No
Description:	Synthetic compound; a pyrroloquinazolinediamine core with a biphenyl group - derivative of SCH-79797 (improved activity); mammalian cell cytotoxicity only observed at 100-1000x concentration to kill bacteria
Year first mentioned:	2020
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C=CC4=C5C(=CC=C43)N=C(N)N=C5N
Isomeric SMILES:	C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C=CC4=C3C=CC5=C4C(=NC(=N5)N)N
InChI:	InChI=1S/C23H19N5/c24-22-21-18-12-13-28(20(18)11-10-19(21)26-23(25)27-22)14-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-13H,14H2,(H4,24,25,26,27)
InChI Key:	CKQXMSDRDDHCOR-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/44531726

External links:
Guide to Pharmacology:	Irresistin-16
Main Source:	https://www.cell.com/cell/fulltext/S0092-8674(20)30567-5