Compound ID | 2328

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TAM16

Class: Small molecule antibacterial agent

Details of activity: Active against Mycobacterium tuberculosis; affects proton motive force; target mycobacterial cell wall biosynthesis (Pks13 inhibitor)
Propensity to select resistant mutants: No
Description: Synthetic compound; novel benzofuran class lead molecule
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 380.44
Iso. SMILES: CNC(=O)C1=C(OC2=C1C(=C(C=C2)O)CN3CCCCC3)C4=CC=C(C=C4)O
InChI Key: PQGCMFVNJWTUFH-UHFFFAOYSA-N
Can. SMILES: CNC(=O)C1=C(C2=CC=C(C=C2)O)OC3=C1C(=C(C=C3)O)CN4CCCCC4
InChI: InChI=1S/C22H24N2O4/c1-23-22(27)20-19-16(13-24-11-3-2-4-12-24)17(26)9-10-18(19)28-21(20)14-5-7-15(25)8-6-14/h5-10,25-26H,2-4,11-13H2,1H3,(H,23,27)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/122644519
Citation: https://www.cell.com/cell/fulltext/S0092-8674(17)30709-2
Patent: US2018111913A1

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