Compound ID | 2329

Update compound information

Pseudouridimycin

Synonym(s): PUM

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Streptococcus sp., Haemophilus influenzae, and Moraxella catarrhalis; inhibits bacterial RNA polymerase
Description: Natural product from a library of extracts of actinobacterial and fungal origin; cytotoxicity towards human macrovascular endothelial and human monocyte at IC50 100 uM (vs bacterial IC50 2-16 uM)
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 486.44
Iso. SMILES: C1=C(C(=O)NC(=O)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)CNC(=O)[C@H](CCC(=O)N)N(C(=O)CN=C(N)N)O)O)O
InChI Key: XDEYHXABZOKKDZ-YFKLLHAASA-N
Can. SMILES: C(CC(=O)N)[C@@H](C(=O)NC[C@@H]1[C@H]([C@H]([C@H](C2=CNC(=O)NC2=O)O1)O)O)N(C(=O)CN=C(N)N)O
InChI: InChI=1S/C17H26N8O9/c18-9(26)2-1-7(25(33)10(27)5-22-16(19)20)15(31)21-4-8-11(28)12(29)13(34-8)6-3-23-17(32)24-14(6)30/h3,7-8,11-13,28-29,33H,1-2,4-5H2,(H2,18,26)(H,21,31)(H4,19,20,22)(H2,23,24,30,32)/t7-,8+,11+,12+,13-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/72792467
Citation: https://www.cell.com/cell/fulltext/S0092-8674(17)30635-9
Patent: EP2890697B1

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.