Compound ID | 233

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RX-04A

Class: Protein synthesis inhibitor (pyrrolocytosine)

Spectrum of activity: Gram-negative
Details of activity: ESKAPE pathogens, bacterial ribosome targeting
Description: Pyrrolocytosine derivative
Institute where first reported: Melinta Therapeutics, USA
Year first mentioned: 2015
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 642.69
Iso. SMILES: NC(NCC[C@H]1N[C@H](C2=CC=C(N3C(N=C4NC(C5=CC(CCC[C@H](C)N)=CC(OC(F)(F)F)=C5F)=CC4=C3)=O)C=C2)CCC1)=N
InChI Key: YRBAWBLJGSQCQB-PZGSVQSZSA-N
Can. SMILES: C[C@@H](CCCC1=CC(=C(C(=C1)OC(F)(F)F)F)C2=CC3=CN(C4=CC=C(C=C4)[C@@H]5CCC[C@@H](CCNC(=N)N)N5)C(=O)N=C3N2)N
InChI: InChI=1S/C32H38F4N8O2/c1-18(37)4-2-5-19-14-24(28(33)27(15-19)46-32(34,35)36)26-16-21-17-44(31(45)43-29(21)42-26)23-10-8-20(9-11-23)25-7-3-6-22(41-25)12-13-40-30(38)39/h8-11,14-18,22,25,41H,2-7,12-13,37H2,1H3,(H4,38,39,40)(H,42,43,45)/t18-,22-,25-/m0/s1
External links:
Citations:
  • https://www.escmid.org/escmid_publications/escmid_elibrary/?q=Pyrrolocytosines&id=2173&L=0&x=0&y=0&tx_solr%5Bsort%5D=relevance%2Basc&tx_solr%5Bfilter%5D%5B1%5D=main_category%253ANew%2BAntibacterial%2BAgents%2B%2526%2BStewardship&tx_solr%5Bfilter%5D%5B2%5D
  • https://journals.asm.org/doi/10.1128/aac.00689-18

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