Compound ID | 2330

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Bacillimidazole G

Class: Natural product antibiotic

Agent Type: Natural product; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Lipopolysaccharide synthesis inhibitor. LpxC inhibitor
Target Pathogen: Active against Lacticasei bacillus paracasei subsp. Paracasei, methicillin-resistant Staphylococcus aureus, and Acinetobacter baumannii LpxC
Description: Natural product from probiotic Bacillus licheniformis; not cytotoxic to mammalian cell lines Wi38 (human foetal lung fibroblast cell line), Chang (human normal liver cell line), and NIH3T3 (mouse fibroblast cell line) at 100 uM (highest concentration tested) vs MIC at 1.56 uM (Gram-positive ) to 6.25 uM (Acinetobacter baumannii ∆lpxC)
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 425.59
Iso. SMILES: CC1=C(C)N(CCC2=CNC3=C2C=CC=C3)C(CCC)=[N+]1CCC4=CNC5=C4C=CC=C5
InChI Key: CELKXWDQNLWDDM-UHFFFAOYSA-N
Can. SMILES: CCCC1=[N+](CCC2=CNC3=C2C=CC=C3)C(=C(C)N1CCC4=CNC5=C4C=CC=C5)C
InChI: InChI=1S/C28H33N4/c1-4-9-28-31(16-14-22-18-29-26-12-7-5-10-24(22)26)20(2)21(3)32(28)17-15-23-19-30-27-13-8-6-11-25(23)27/h5-8,10-13,18-19,29-30H,4,9,14-17H2,1-3H3/q+1
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jnatprod.2c01032

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