Compound ID | 2331

Update compound information

Artocarpin

Synonym(s): AH-5

Class: Membrane-active agent

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent. Disrupts integrity of cytoplasmic membrane
Target Pathogen: Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Staphylococcus aureus, Enterococcus sp., vancomycin-susceptible Enterococcus, and vancomycin-resistant Enterococcus
Description: Natural product from Artocarpus hirsutus bark; cytotoxic to vero cells at 80 ug/ml vs MIC (Staphylococcus aureus) 2 ug/ml; synergistic effect with gentamicin and linezolid
Year first mentioned: 2017
Development status: Experimental
Chemical structure(s):
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Molecular weight: 436.5
Iso. SMILES: CC(C)/C=C/C1=C(C=C2C(=C1O)C(=O)C(=C(O2)C3=C(C=C(C=C3)O)O)CC=C(C)C)OC
InChI Key: KRGDFVQWQJIMEK-RMKNXTFCSA-N
Can. SMILES: CC(C)/C=C/C1=C(C=C2C(=C1O)C(=O)C(=C(C3=C(C=C(C=C3)O)O)O2)CC=C(C)C)OC
InChI: InChI=1S/C26H28O6/c1-14(2)6-9-18-21(31-5)13-22-23(24(18)29)25(30)19(10-7-15(3)4)26(32-22)17-11-8-16(27)12-20(17)28/h6-9,11-14,27-29H,10H2,1-5H3/b9-6+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5458461
Citations:
  • https://www.tandfonline.com/doi/full/10.1080/23312009.2017.1416557
  • https://pubs.acs.org/doi/10.1021/acs.jnatprod.2c00621

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