Compound ID | 2332

Update compound information

Micrococcin P2

Synonym(s): MP2

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive
Details of activity: Active against Clostridioides difficile; inhibits protein synthesis
Description: Natural product (tested in this study from total synthesis); noncytotoxic to mammalian cells up to 40 uM (MIC 1 ug/ml); thiopeptide-type
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1142.37
Iso. SMILES: C/C=C\1/C2=NC(=CS2)C(=O)N[C@H](C3=NC(=CS3)C(=O)N[C@H](C4=NC(=CS4)C5=C(C=CC(=N5)C6=NC(=CS6)C7=NC(=CS7)C(=O)N/C(=C\C)/C(=O)NCC(=O)C)C8=NC(=CS8)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)[C@@H](C)O)C(C)C
InChI Key: XLMXLFRJEYNHMO-RRXYFVOQSA-N
Can. SMILES: C/C=C(/C(=O)NCC(=O)C)\NC(=O)C1=CSC(=N1)C2=CSC(=N2)C3=NC4=C(C=C3)C5=NC(=CS5)C(=O)N[C@@H]([C@@H](C)O)C(=O)N/C(=C\C)/C6=NC(=CS6)C(=O)N[C@@H](C(C)C)C7=NC(=CS7)C(=O)N[C@@H]([C@@H](C)O)C8=NC4=CS8
InChI: InChI=1S/C48H47N13O9S6/c1-8-24(37(65)49-12-20(5)62)51-38(66)28-15-73-46(56-28)32-18-74-45(58-32)26-11-10-23-36(50-26)27-13-75-48(53-27)35(22(7)64)61-41(69)31-17-76-47(57-31)33(19(3)4)59-39(67)30-16-72-44(55-30)25(9-2)52-42(70)34(21(6)63)60-40(68)29-14-71-43(23)54-29/h8-11,13-19,21-22,33-35,63-64H,12H2,1-7H3,(H,49,65)(H,51,66)(H,52,70)(H,59,67)(H,60,68)(H,61,69)/b24-8-,25-9-/t21-,22-,33+,34+,35+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/402380639
Citation: https://pubs.acs.org/doi/10.1021/acs.jnatprod.2c00120

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