Compound ID | 2333

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Mindapyrrole B

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Enterococcus faecium
Description: Natural product from Pseudomonas aeruginosa strain 1682U.R.0a.27; pyoluteorin analogues; cytotoxicity towards MDCK mammalian cell line observed at IC50 67 ug/ml vs MIC 2-8 ug/ml; analogues with non-selective activity reported
Institute where first reported: The Marine Science Institute, University of the Philippines, Diliman, Quezon City 1101, Philippines
Year first mentioned: 2019
Development status: Experimental
Chemical structure(s):
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Molecular weight: 731.39
Iso. SMILES: C1=CC=C(C(=C1)C2=NC(=CS2)C(C3=C(C(=C(C=C3)O)C(=O)C4=CC(=C(N4)Cl)Cl)O)C5=C(C(=C(C=C5)O)C(=O)C6=CC(=C(N6)Cl)Cl)O)O
InChI Key: PGJSUOOMNBEQDS-UHFFFAOYSA-N
Can. SMILES: C1=CC(=C(C=C1)O)C2=NC(=CS2)C(C3=CC=C(C(=C3O)C(=O)C4=CC(=C(Cl)N4)Cl)O)C5=CC=C(C(=C5O)C(=O)C6=CC(=C(Cl)N6)Cl)O
InChI: InChI=1S/C32H19Cl4N3O7S/c33-15-9-17(37-30(15)35)28(45)24-21(41)7-5-13(26(24)43)23(19-11-47-32(39-19)12-3-1-2-4-20(12)40)14-6-8-22(42)25(27(14)44)29(46)18-10-16(34)31(36)38-18/h1-11,23,37-38,40-44H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/145720857
Citation: https://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00979

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