Berberine

Class: Efflux pump inhibitor

Spectrum of activity:	Gram-negative
Details of activity:	Active against MexXY-OprM system in Pseudomonas aeruginosa
Description:	Natural product from plants (ex: Hydrastis Canadensis, Berberis aristata, and many others); no haemolytic activity detected (highest concentration tested at 320 ug/ml); synergistic effect with tobramycin
Year first mentioned:	2010
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C5C(=C4)OCO5
Isomeric SMILES:	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC
InChI:	InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1
InChI Key:	YBHILYKTIRIUTE-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/2353

External links:
Guide to Pharmacology:	berberine
Main Source:	https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b00317
Citation:	https://www.sciencedirect.com/science/article/pii/S0278691510000852?via%3Dihub