Compound ID | 2338
Somuncurin-1
Class: Antimicrobial peptide
| Agent Type: | Natural product; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Membrane-active agent |
| Target Pathogen: | Active against Staphylococcus aureus and Escherichia coli |
| Description: | Natural product from skin of Pleurodema somuncurense; showed <5% haemolysis to human red blood cells at MIC concentration in E. coli (180 uM); does not effect ROS production in human microglial cell line CHME3 with LPS (no inflammatory reaction); somuncurin-type |
| Year first mentioned: | 2020 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b00906 |
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