Compound ID | 2339

Update compound information

Arsinothricin

Synonym(s): AST  |  2-amino-4-(hydroxymethylarsinoyl)butanoate

Class: Natural product antibiotic

Agent Type: Natural product; Direct acting;
Spectrum of activity: Gram-positive, Gram-negative & Antimycobacterial
Mechanism of action: Glutamine synthetase inhibitor
Target Pathogen: Active against Escherichia coli, Corynebacterium glutamicum, Mycobacterium bovis, and Enterobacter cloacae
Description: Natural product from rice rhizosphere microbe Burkholderia gladioli GSRB05
Year first mentioned: 2018
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 224.07
Iso. SMILES: [O-]C(C([NH3+])CC[As]([O-])(C)=O)=O
InChI Key: CXTQPLOKUBDLTK-UHFFFAOYSA-M
Can. SMILES: C[As](=O)(CCC(C(=O)[O-])[NH3+])[O-]
InChI: InChI=1S/C5H12AsNO4/c1-6(10,11)3-2-4(7)5(8)9/h4H,2-3,7H2,1H3,(H,8,9)(H,10,11)/p-1
External links:
Citations:
  • https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c00522
  • https://www.nature.com/articles/s42003-019-0365-y#Sec2
    • Patent: US11298335B2

    AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.