Compound ID | 234

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RX-04B

Class: Protein synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Protein synthesis inhibitor. Targets 50S ribosomal subunit
Target Pathogen: Active against Enterobacteriaceae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Serratia
Description: Pyrrolocytosine derivative
Institute where first reported: Melinta Therapeutics, USA
Year first mentioned: 2015
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 664.28
Iso. SMILES: CC(NCC[C@H]1N[C@H](C2=CC=C(N3C(N=C4NC(C5=CC(CCC[C@H](C6CC6)N)=CC(Cl)=C5F)=CC4=C3)=O)C=C2SC)CCC1)=N
InChI Key: CTLUOHGTHUHSRM-NSQMQTOTSA-N
Can. SMILES: CC(=N)NCC[C@@H]1CCC[C@@H](C2=CC=C(C=C2SC)N3C=C4C=C(C5=C(C(=CC(=C5)CCC[C@H](C6CC6)N)Cl)F)NC4=NC3=O)N1
InChI: InChI=1S/C35H43ClFN7OS/c1-20(38)40-14-13-24-6-4-8-30(41-24)26-12-11-25(18-32(26)46-2)44-19-23-17-31(42-34(23)43-35(44)45)27-15-21(16-28(36)33(27)37)5-3-7-29(39)22-9-10-22/h11-12,15-19,22,24,29-30,41H,3-10,13-14,39H2,1-2H3,(H2,38,40)(H,42,43,45)/t24-,29+,30-/m0/s1
External links:
Citations:
  • https://www.escmid.org/escmid_publications/escmid_elibrary/?q=Pyrrolocytosines&id=2173&L=0&x=0&y=0&tx_solr%5Bsort%5D=relevance%2Basc&tx_solr%5Bfilter%5D%5B1%5D=main_category%253ANew%2BAntibacterial%2BAgents%2B%2526%2BStewardship&tx_solr%5Bfilter%5D%5B2%5D
  • https://journals.asm.org/doi/10.1128/aac.00689-18

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