Compound ID | 2343

Update compound information

Tamarixetin

Synonym(s): 4′-O-methylquercetin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Indirect acting; Antivirulence;
Spectrum of activity: Gram-positive
Mechanism of action: ClpP inhibitor
Target Pathogen: Active against Staphylococcus aureus
Description: Natural product from Tamarix troupii; flavonoid; enhances activity of cefotaxime; does not affect growth of S. aureus and mammalian cell lines HEK-293T, A549, and HepG2
Year first mentioned: 2018
Development status: Experimental
Chemical structure(s):
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Molecular weight: 316.26
Iso. SMILES: COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
InChI Key: FPLMIPQZHHQWHN-UHFFFAOYSA-N
Can. SMILES: COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O)O)O2)O)O
InChI: InChI=1S/C16H12O7/c1-22-11-3-2-7(4-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5281699
Citations:
  • https://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00155
  • https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00668
  • https://pubs.acs.org/doi/10.1021/acs.jnatprod.2c00138

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