Compound ID | 2344

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Acidonemycin

Class: Antivirulence agent

Agent Type: Natural product; Indirect acting; Antivirulence;
Spectrum of activity: Gram-positive
Mechanism of action: Targets virulence peptide PSMα and δ-toxin
Target Pathogen: Active against methicillin-resistant Staphylococcus aureus
Description: Natural product from Streptomyces indonesiensis DSM41759; angucycline antibiotic
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 514.48
Iso. SMILES: OC=1C=CC2=C(C1C3C=4C=CC=C(O[C@@H]5O[C@H](C(OC)=O)[C@@H](O)C(O)[C@H]5O)C4C(O3)=O)C(C[C@H](C2)C)=O
InChI Key: FLNNNSAACYMVIC-MSZXCUOASA-N
Can. SMILES: C[C@H]1CC2=CC=C(C(=C2C(=O)C1)C3C4=CC=CC(=C4C(=O)O3)O[C@H]5[C@@H](C([C@@H]([C@@H](C(=O)OC)O5)O)O)O)O
InChI: InChI=1S/C26H26O11/c1-10-8-11-6-7-13(27)18(16(11)14(28)9-10)22-12-4-3-5-15(17(12)24(32)36-22)35-26-21(31)19(29)20(30)23(37-26)25(33)34-2/h3-7,10,19-23,26-27,29-31H,8-9H2,1-2H3/t10-,19?,20-,21+,22?,23-,26+/m0/s1
External links:
Citation: https://pubs.acs.org/doi/10.1021/acs.jnatprod.3c00502

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