Compound ID | 2345

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Cudraflavone C

Synonym(s): Cud C

Class: Natural product antibiotic

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Staphylococcus aureus, Enterococcus sp., and vancomycin-resistant Enterococcus sp.
Description: Natural product from Artocarpus hirsutus Lam.; CC50 (cytotoxic concentration) in Vero cells at 50-100 ug/ml vs MIC at 2 ug/ml; active against Gram-negatives in presence of sub-lethal concentrations of PMBN; synergistic effect with gentamicin
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 422.47
Iso. SMILES: CC(=CCC1=C(C2=C(C=C1O)OC(=C(C2=O)CC=C(C)C)C3=C(C=C(C=C3)O)O)O)C
InChI Key: MUUDYSFWQUSAOO-UHFFFAOYSA-N
Can. SMILES: CC(=CCC1=C(C=C2C(=C1O)C(=O)C(=C(C3=C(C=C(C=C3)O)O)O2)CC=C(C)C)O)C
InChI: InChI=1S/C25H26O6/c1-13(2)5-8-16-20(28)12-21-22(23(16)29)24(30)18(9-6-14(3)4)25(31-21)17-10-7-15(26)11-19(17)27/h5-7,10-12,26-29H,8-9H2,1-4H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5319924
Citation: https://pubs.acs.org/doi/10.1021/acs.jnatprod.1c00578

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