Compound ID | 2349

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Salvarsan

Synonym(s): Arsphenamine  |  diamino dihydroxy arsenobenzol

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Gram-negative
Mechanism of action: Unknown
Target Pathogen: Active against Treponema pallidum spirochaetes
Description: Synthetic compound
Year first mentioned: 1907
Development status: Inactive
Reason dropped: Toxicity
Chemical structure(s):
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Molecular weight: 439
Iso. SMILES: C1=CC(=C(C=C1[As]=[As]C2=CC(=C(C=C2)O)N)N)O.Cl.Cl
InChI Key: VLAXZGHHBIJLAD-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1)O)N)[As]=[As]C2=CC=C(C(=C2)N)O.Cl.Cl
InChI: InChI=1S/C12H12As2N2O2.2ClH/c15-9-5-7(1-3-11(9)17)13-14-8-2-4-12(18)10(16)6-8;;/h1-6,17-18H,15-16H2;2*1H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/8774
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726818/#:~:text=Salvarsan%20was%20tested%20in%20patients,his%20presumptive%20wonder%20drug%2C%20Tuberculin.
  • https://journals.physiology.org/doi/pdf/10.1152/physrev.1925.5.1.63

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