Compound ID | 235

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RX-04C

Class: Protein synthesis inhibitor (pyrrolocytosine)

Spectrum of activity: Gram-negative
Details of activity: ESKAPE pathogens, bacterial ribosome targeting
Description: Pyrrolocytosine derivative
Institute where first reported: Melinta Therapeutics, USA
Year first mentioned: 2015
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 626.14
Iso. SMILES: CC(NCC[C@H]1N[C@H](C2=CC=C(N3C(N=C4NC(C5=CC(CCC[C@H](CO)N)=CC(Cl)=C5F)=CC4=C3)=O)C=C2F)CCC1)=N
InChI Key: NSABWPWQTJEACJ-WENCSYSZSA-N
Can. SMILES: CC(=N)NCC[C@@H]1CCC[C@@H](C2=CC=C(C=C2F)N3C=C4C=C(C5=C(C(=CC(=C5)CCC[C@H](CO)N)Cl)F)NC4=NC3=O)N1
InChI: InChI=1S/C32H38ClF2N7O2/c1-18(36)38-11-10-22-6-3-7-28(39-22)24-9-8-23(15-27(24)34)42-16-20-14-29(40-31(20)41-32(42)44)25-12-19(13-26(33)30(25)35)4-2-5-21(37)17-43/h8-9,12-16,21-22,28,39,43H,2-7,10-11,17,37H2,1H3,(H2,36,38)(H,40,41,44)/t21-,22+,28+/m1/s1
External links:
Citations:
  • https://www.escmid.org/escmid_publications/escmid_elibrary/?q=Pyrrolocytosines&id=2173&L=0&x=0&y=0&tx_solr%5Bsort%5D=relevance%2Basc&tx_solr%5Bfilter%5D%5B1%5D=main_category%253ANew%2BAntibacterial%2BAgents%2B%2526%2BStewardship&tx_solr%5Bfilter%5D%5B2%5D
  • https://journals.asm.org/doi/10.1128/aac.00689-18

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