Compound ID | 2356
Vancomycin GR-MoTr conjugate
Synonym(s): V-r8
Class: Glycopeptide
| Spectrum of activity: | Gram-positive |
| Details of activity: | Active against methicillin-resistant Staphylococcus aureus (planktonic and biofilm) and vancomycin-resistant Enterococci; targets lipid II and disrupts integrity of cytoplasmic membrane |
| Description: | Semi-synthetic compound; vancomycin attached to D-octaarginine (r8) - a cell-penetrating guanidinium-rich molecular transporter (GR-MoTr); shows antibiofilm activity with MBEC 9.5-20 uM vs MRSA; minimal haemolytic activity (HC50 >320 uM), 50% cytotoxicity towards HaCaT cells observed at 10x MIC; reduced biofilm bacterial load in murine wound model |
| Institute where first reported: | Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305, United States |
| Year first mentioned: | 2018 |
| Development status: | Experimental |
| External links: | |
| Citations: |
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| Patent: | US6306993B1 |
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