Compound ID | 2360
Apralog 57β
Synonym(s): apramycin-5-O-β-d-ribofuranoside | 57β
Class: Aminoglycoside
| Agent Type: | Semisynthetic; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Unknown |
| Target Pathogen: | Active against Escherichia coli and E. coli with AMEs , Klebsiella pneumoniae, Enterobacter, Acinetobacter baumannii, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and methicillin resistant with AMEs |
| Description: | Synthetic compound based on 2-deoxystreptamine; better clearance of E. coli thigh infection model in mice compared to apramycin |
| Year first mentioned: | 2020 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/jacs.9b11601 |
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