Compound ID | 2361

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Concolactam

Class: Antivirulence agent

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus SrtA
Description: Natural product from Streptomyces sp. UTZ13; no cytotoxicity observed in cancer cell lines at IC50 >100 uM (highest tested)
Year first mentioned: 2023
Development status: Experimental
Chemical structure(s):
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Molecular weight: 363.49
Iso. SMILES: O=C1/C=C/C=C/[C@@]2([H])[C@](C=C[C@@]3([H])[C@]2([H])C[C@H](O)C=C3)([H])/C=C/C=C/C=C\[C@@H](C)CN1
InChI Key: SGUODVFRENADOS-SHNACTLDSA-N
Can. SMILES: C[C@@H]1/C=C\C=C\C=C\[C@]2([H])C=C[C@]3([H])C=C[C@H](C[C@]3([H])[C@@]2([H])/C=C/C=C/C(=O)NC1)O
InChI: InChI=1S/C24H29NO2/c1-18-8-4-2-3-5-9-19-12-13-20-14-15-21(26)16-23(20)22(19)10-6-7-11-24(27)25-17-18/h2-15,18-23,26H,16-17H2,1H3,(H,25,27)/b3-2+,8-4-,9-5+,10-6+,11-7+/t18-,19-,20-,21-,22+,23+/m1/s1
External links:
Citation: https://pubs.acs.org/doi/10.1021/jacs.2c11527

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