Compound ID | 2362

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Albofungin

Synonym(s): Antibiotic P-42-1

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Acinetobacter baumannii, Escherichia coli, Staphylococcus aureus and methicillin-resistant Staphylococcus aureus; potentially has other mechanism of action due to activity towards Gram-negatives but has been shown to inhibit transglycosylase activity (cell wall synthesis inhibitor)
Description: Natural product from crude extracts library (extract 31081); reported previously as a natural product from Actinomyces species
Year first mentioned: 1973
Development status: Experimental
Chemical structure(s):
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Molecular weight: 520.49
Iso. SMILES: CC1=CC2=CC3=C(C4=C(C5=C(C6=C4[C@@H](C3)OCO6)C(=O)C7=C(O5)[C@@H](CC[C@@H]7O)OC)O)C(=C2C(=O)N1N)O
InChI Key: LYKFTVCDYGGLGW-BFHYXJOUSA-N
Can. SMILES: CC1=CC2=C(C(=C3C(=C2)C[C@@H]4C5=C(C6=C(C(=C35)O)OC7=C([C@H](CC[C@H]7OC)O)C6=O)OCO4)O)C(=O)N1N
InChI: InChI=1S/C27H24N2O9/c1-9-5-10-6-11-7-14-18-19(15(11)21(31)16(10)27(34)29(9)28)23(33)26-20(25(18)37-8-36-14)22(32)17-12(30)3-4-13(35-2)24(17)38-26/h5-6,12-14,30-31,33H,3-4,7-8,28H2,1-2H3/t12-,13+,14+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/20054819
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/26/2/26_2_65/_article
  • https://pubs.acs.org/doi/10.1021/jacs.7b13205

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