Compound ID | 2367

Update compound information

Promysalin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Targets succinate dehydrogenase/ succinate dehydrogenase inhibitor
Target Pathogen: Active against Pseudomonas aeruginosa
Description: Natural product from Pseudomonas sp. from rhizosphere; showed 50-fold difference in IC50 between mammalian and bacterial succinate dehydrogenase
Year first mentioned: 2011
Development status: Experimental
Chemical structure(s):
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Molecular weight: 476.61
Iso. SMILES: CCCCCCC(CCCCCC(C(=O)N)O)OC(=O)[C@@H]1CCCN1C(=O)C2=CC=CC=C2O
InChI Key: WMHMGPUINRVYES-SWCONJRYSA-N
Can. SMILES: CCCCCCC(CCCCCC(C(=O)N)O)OC(=O)[C@@H]1CCCN1C(=O)C2=C(C=CC=C2)O
InChI: InChI=1S/C26H40N2O6/c1-2-3-4-6-12-19(13-7-5-8-17-23(30)24(27)31)34-26(33)21-15-11-18-28(21)25(32)20-14-9-10-16-22(20)29/h9-10,14,16,19,21,23,29-30H,2-8,11-13,15,17-18H2,1H3,(H2,27,31)/t19?,21-,23?/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/122380159
Citations:
  • https://pubs.acs.org/doi/10.1021/jacs.5b04767
  • https://www.sciencedirect.com/science/article/pii/S1074552111003140?via%3Dihub
  • https://pubs.acs.org/doi/10.1021/jacs.7b11212

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