Compound ID | 2376

Update compound information

Chrysophaentin A

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell division inhibitor. FtsZ inhibitor
Target Pathogen: Active against Staphylococcus aureus, Enterococcus faecium, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus faecium
Description: Natural product from chrysophyte alga Chrysophaeum taylori; cytotoxicity observed in human colon tumour cell line HCT-116, murine leukaemia cell line P388, and mammalian cell line BSC-1 as high as 100 ug/ml (vs 1.8-3.9 ug/ml MIC)
Year first mentioned: 2010
Development status: Experimental
Chemical structure(s):
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Molecular weight: 678.34
Iso. SMILES: C1/C=C(\CC2=CC(=C(C(=C2)O)OC3=C(C=C(C(=C3)C/C=C(\CC4=C(C(=CC(=C4)O)O)OC5=C(C=C(C1=C5)O)Cl)/Cl)O)Cl)O)/Cl
InChI Key: QGYSNOUOCKPDTD-KNPOPJAVSA-N
Can. SMILES: C1/C=C(\CC2=CC(=C(C(=C2)O)OC3=CC(=C(C=C3Cl)O)C/C=C(\CC4=C(C(=CC(=C4)O)O)OC5=CC1=C(C=C5Cl)O)/Cl)O)/Cl
InChI: InChI=1S/C32H24Cl4O8/c33-19-3-1-16-10-29(22(35)13-24(16)38)43-31-18(9-21(37)12-28(31)42)8-20(34)4-2-17-11-30(23(36)14-25(17)39)44-32-26(40)6-15(5-19)7-27(32)41/h3-4,6-7,9-14,37-42H,1-2,5,8H2/b19-3+,20-4+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/46872004
Citations:
  • https://pubs.acs.org/doi/10.1021/jacs.0c04917
  • https://pubs.acs.org/doi/10.1021/ja102100h
    • Patent: US2013331460A1

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