Compound ID | 2377
Beta-peptide polymer P4
Synonym(s): Secondary Amine Pendant beta-Peptide polymer | Secondary Amine Pendant β-Peptide polymer | β-peptide polymer P4
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Staphylococcus aureus, carbenicillin- and piperacillin-resistant Escherichia coli, sulfamethoxazole- and tetracycline-resistant Pseudomonas aeruginosa, multidrug-resistant strains (E. coli, Acinetobacter baumannii, P. aeruginosa, S. aureus), and S. epidermidis; membrane-active agent (cytoplasmic membrane) |
| Description: | Synthetic compound (HDP mimic); no dermal toxicity observed when tested for topical application on mice; 4.6 log reduction of bacterial load in MRSA wound infection model in mice (vancomycin control showed 3 log reduction) |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://pubs.acs.org/doi/10.1021/jacs.1c10659 |
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