Compound ID | 2380

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Liproxstatin-1

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii; disrupts integrity of the outer membrane in Gram-negative
Description: Synthetic compound; ferroptosis inhibitor in human cells; an analogue of MAC-0549481; potentiates rifampicin, novobiocin, erythromycin, and linezolid
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 340.85
Iso. SMILES: C1CNCCC12C(=NCC3=CC(=CC=C3)Cl)NC4=CC=CC=C4N2
InChI Key: YAFQFNOUYXZVPZ-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1)NC3(CCNCC3)C(=NCC4=CC=CC(=C4)Cl)N2
InChI: InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135735917
Citation: https://pubs.acs.org/doi/10.1021/acschembio.1c00179

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