Compound ID | 2381

Update compound information

MAC-0568743

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Membrane-active agent. Disrupts integrity of the outer membrane in Gram-negative
Target Pathogen: Active against Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa
Description: Synthetic compound; a cationic amphiphile; potentiates rifampicin, novobiocin, erythromycin, and linezolid
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 318.84
Iso. SMILES: ClC1=CC(CC2=CC=CC=C2)=C(OCCNCCCN)C=C1
InChI Key: NLNWGFFIXAPUMJ-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)CC2=CC(=CC=C2OCCNCCCN)Cl
InChI: InChI=1S/C18H23ClN2O/c19-17-7-8-18(22-12-11-21-10-4-9-20)16(14-17)13-15-5-2-1-3-6-15/h1-3,5-8,14,21H,4,9-13,20H2
External links:
Citation: https://pubs.acs.org/doi/10.1021/acschembio.1c00179

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